10.1089/ars.2012.4964 42 WinterbournC
Because of this diversity, it is challenging to establish global reference ranges and to determine precise intervention thresholds [65, 66]
Among them, capsaicin (8-methyl N-vanillyl-6-noneamide, CAP), as a key active component of peppers, has been shown to have potential therapeutic effects on central nervous system (CNS) diseases such as Parkinsons disease, epilepsy, and depression
Some possible theories concerning the causes of fatigue have included: elevated body temperature (in RRMS patients) [164], sleep disturbances and depression [165, 166], proinflammatory cytokines [167], reduced metabolism and degeneration of cerebral and deep gray matter structures [168, 169], reduced connectivity [170], and reduced perfusion of deep gray matter [11]
Dec 1992;6(4):209-21